Suomennosapua lääketieteelliseen tekstinpätkään (englanniksi)

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Breast cancer at an early age is more likely to be associated with an increased familial risk, especially in women harboring a germline BRCA1 mutation. In a study of women with breast cancer diagnosed before age 30, BRCA1, BRCA2, and TP53 mutations were found in about half who had strong family histories of breast cancer and in less than 10% of women with non-familial breast cancer. Patients with familial PTEN mutations (Cowden syndrome) also have an increased risk for early breast cancer.