Oliko se Panadol vai Burana, jota ei sais ottaa humalassa/krapulassa?

http: //www. klik. fi/kysymys/kysymys9-02. pdf

Lisää:

Myös itsehoidosta saatavilla kipulääkkeillä voi olla yhteisvaikutuksia alkoholin kanssa. Tulehduskipulääkkeiden, kuten ibuprofeenin (esim. Burana, Ibusal, Ibumax) tai ketoprofeenin (esim. Ketorin, Orudis) ja alkoholin yhteiskäytöstä voi seurata maha-suolikanavan ärtyminen. Haitat eivät kuitenkaan yleensä tule esiin satunnaisesti kipulääkettä käytettäessä. Sen sijaan

parasetamolin (esim. Panadol, Para-tabls) ja alkoholin yhteiskäyttö aiheuttaa huomattavan maksavaurioiden riskin, joten niiden yhteiskäyttöä ei suositella lainkaan.

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Tässä ihan uusinta tietoa:

Hepatotoxicity from therapeutic doses of paracetamol is unlikely in patients who consume moderate to large amounts of alcohol daily.

However, patients with severe alcoholism should be instructed or supervised about the correct dosage of paracetamol. The depression often associated with alcoholism may make them more likely to take an overdose of paracetamol. Furthermore, the memory loss often seen in severe alcoholism may make patients unaware of having taken more than the recommended dose.

In the UK limiting the single sale of paracetamol tablets or capsules to 16 in general stores and 32 in pharmacies has been correlated with a reduction in the number of overdoses with paracetamol. Restricting the availability of paracetamol to patients with severe alcoholism and/or depression associated with alcohol abuse may similarly be associated with a decreased number of overdoses of paracetamol.

Overdoses of paracetamol are a major problem. The occurrence of hepatotoxicity in patients who consume alcohol regularly and who take therapeutic doses of paracetamol is a very contentious topic. At this stage, paracetamol appears to be a reasonable analgesic or antipyretic drug to use in compliant patients who consume alcohol regularly. However, longer-term controlled studies are still required to clarify further the safety of paracetamol when taken regularly in combination with moderate to large amounts of alcohol.

After a recent review, the Therapeutic Goods Administration' s decision that no warning regarding alcohol should be added to labels on paracetamol products seems reasonable.

Ja tässä muutama referenssi:

References

1. Draganov P, Durrence H, Cox C, Reuben A. Alcohol-acetaminophen syndrome. Even moderate drinkers are at risk. Postgrad Med 2000;107:189-95.

2. Dart RC, Kuffner EK, Rumack BH. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. Am JTher 2000;7:123-34.

3. Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000;49:291-301.

4. Thummel KE, Slattery JT, Ro H, Chien JY, Nelson SD, Lown KE, et al. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin PharmacolTher 2000;67:591-9.

5. Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L. Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. Arch Intern Med 2001;161:2247-52.

6. Lauterburg BH. Analgesics and glutathione. Am J Ther 2002;9:225-33.

7. Hochberg MC. Reply [letter]. Arthritis Rheum 2001;44:2455-6.

8. Medicines Evaluation Committee. Review of non-prescription analgesics: an update. Canberra: Commonwealth Department of Health and Ageing; 2003.

Artikkeli on Australian lääketieteen julkaisusta, löytyy toki muistakin lehdistä.

Burana saattaa ärsyttää mahan limakalvoja. Yks panadol 500 mg ei ole maksatoksinen, panadoliakin saa aika paljon vetää ennen kun maksa vaurioituu. Ei tuo buranakaan 1 kpl haittaa tee. Mutta mieluummin se panadol.

T: SH

Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of this medication needed to get relief from your pain, swelling, or fever. Avoid taking ibuprofen if you are taking aspirin to prevent stroke or heart attack. Ibuprofen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form). Do not drink alcohol while taking this medication. Alcohol can increase your risk of stomach bleeding caused by ibuprofen.



Tuloksia voidaan soveltaa muihin nsaid:hin.



proviisori

Joko juo kohtuudella tai kärsii sitten hiljaa sen krapulansa.



proviisori

Satunnaisesta käytöstä ei ole haittaa kummassakaan tapauksessa!

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