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Selfish sperm see older fathers pass on more disease-causing mutations

Vierailija
09.10.2025 |

https://www.newscientist.com/article/2499225-selfish-sperm-see-older-fa…

Older men are more likely to pass on disease-causing mutations to their children because of the faster growth of mutant cells in the testes with age

The risk of older fathers passing on disease-causing mutations to their children is higher than we thought. Genome sequencing has revealed that among men in their early thirties, around 1 in 50 sperm have a disease-causing mutation which rises to nearly 1 in 20 by the age of 70.

The paper clearly shows that older fathers have a higher risk of passing on more pathogenic mutations, says Raheleh Rahbari at the Wellcome Sanger Institute in the UK.

 

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